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Cardiomyocytes as effectors of nitric oxide signalling.

Abstract:

Nitric oxide (NO) generated constitutively within the heart has long been known to influence myocardial function; however, the precise nature of these effects has been controversial--at least in part--because of the experimental use of non-isoform-selective inhibitors of NO synthases (NOS) and unwarranted extrapolation from results obtained with NO donors. Recent studies using NOS-selective inhibitors and genetically modified models are beginning to redress the balance. It is well established...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Journal:
Cardiovascular research
Volume:
75
Issue:
2
Pages:
315-326
Publication date:
2007-07-05
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:3d68886c-d252-47a9-a0a0-abc327e2d49d
Source identifiers:
105032
Local pid:
pubs:105032

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