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Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.

Abstract:

Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in schizophrenia, but the mediating mechanisms are unknown. Here we identify a genetically regulated, pharmacologically targetable, risk pathway associated with schizophrenia and with ErbB4 genetic variation involving increased expression of a PI3K-linked ErbB4 receptor (CYT-1) and the phosphoinositide 3-kinase subunit, p110δ (PIK3CD). In human lymphoblasts, NRG1-mediated phosphatidyl-inositol,3,4,5 triphosphate ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1206118109

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
30
Pages:
12165-12170
Publication date:
2012-07-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
348898

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