Journal article
Activation-induced markers detect vaccine-specific CD4⁺ T cell responses not measured by assays conventionally used in clinical trials
- Abstract:
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Immunogenicity of T cell-inducing vaccines, such as viral vectors or DNA vaccines and Bacillus Calmette-Guérin (BCG), are frequently assessed by cytokine-based approaches. While these are sensitive methods that have shown correlates of protection in various vaccine studies, they only identify a small proportion of the vaccine-specific T cell response. Responses to vaccination are likely to be heterogeneous, particularly when comparing prime and boost or assessing vaccine performance across di...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.5MB)
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- Publisher copy:
- 10.3390/vaccines6030050
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Authors
Funding
+ European and Developing Countries Clinical Trials Partnership
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Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- Vaccines Journal website
- Volume:
- 6
- Issue:
- 3
- Article number:
- 50
- Publication date:
- 2018-07-31
- Acceptance date:
- 2018-07-30
- DOI:
- ISSN:
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2076-393X
- Pmid:
-
30065162
- Source identifiers:
-
895483
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:895483
- UUID:
-
uuid:3d56df00-60c6-437e-ae00-63402926ead1
- Local pid:
- pubs:895483
- Deposit date:
- 2018-08-09
Terms of use
- Copyright holder:
- © 2018 Bowyer, et al Licensee MDPI, Basel, Switzerland
- Copyright date:
- 2018
- Notes:
- This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
- Licence:
- CC Attribution (CC BY)
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