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Journal article

Activation-induced markers detect vaccine-specific CD4⁺ T cell responses not measured by assays conventionally used in clinical trials

Abstract:

Immunogenicity of T cell-inducing vaccines, such as viral vectors or DNA vaccines and Bacillus Calmette-Guérin (BCG), are frequently assessed by cytokine-based approaches. While these are sensitive methods that have shown correlates of protection in various vaccine studies, they only identify a small proportion of the vaccine-specific T cell response. Responses to vaccination are likely to be heterogeneous, particularly when comparing prime and boost or assessing vaccine performance across di...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/vaccines6030050

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Oxford college:
Queens College
Role:
Author
ORCID:
0000-0002-2058-4045
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Role:
Author
ORCID:
0000-0001-9111-2486
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
ORCID:
0000-0003-2944-787X
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
ORCID:
0000-0002-7005-1546
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Jenner Institute
Role:
Author
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More from this funder
Funding agency for:
Hill, A
Publisher:
MDPI Publisher's website
Journal:
Vaccines Journal website
Volume:
6
Issue:
3
Article number:
50
Publication date:
2018-07-31
Acceptance date:
2018-07-30
DOI:
ISSN:
2076-393X
Pmid:
30065162
Source identifiers:
895483
Language:
English
Keywords:
Pubs id:
pubs:895483
UUID:
uuid:3d56df00-60c6-437e-ae00-63402926ead1
Local pid:
pubs:895483
Deposit date:
2018-08-09

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