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Particle-based multiscale modeling of intracellular calcium dynamics

Abstract:

Intracellular calcium is regulated by the release of Ca$^{2+}$ ions from the endoplasmic reticulum via inisitol-4,5-triphosphate receptor channels. The resulting dynamics are highly diverse, lead to local calcium "puffs" as well as global waves propagating through cells. Local fluctuations in the number of calcium ions play a crucial role in the onset of these features. Previous modeling studies have focused on stochastic channel models coupled to deterministic diffusion of ions, thereby negl...

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Publication status:
Submitted
Peer review status:
Not peer reviewed

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Authors


Dobramysl, Ulrich More by this author
Rüdiger, Sten More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Publication date:
2015-04-01
URN:
uuid:3d568248-31ba-4eef-8d1e-3aae8bc1be24
Source identifiers:
516328
Local pid:
pubs:516328

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