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Journal article

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Abstract:

The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incompletely understood. Here we identify sequence signatures enriched in genomic p53-binding sites modulated by the transcription cofactor iASPP. Moreover, our p53–iASPP crystal structure reveals that iAS...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1909393116

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Expand authors...
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
35
Pages:
17470-17479
Publication date:
2019-08-08
Acceptance date:
2019-07-11
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
1031509
Keywords:
Pubs id:
pubs:1031509
UUID:
uuid:3d32eed3-c4cd-455b-a410-9b1966af012e
Local pid:
pubs:1031509
Deposit date:
2019-07-12

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