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Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes.

Abstract:

Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important roles in clathrin-mediated endocytosis. Here, we present the structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5- bisphosphate [PtdIns(4,5)P2] via a lysine-rich motif. This motif is found in other proteins predicted to have domains of similar structure (for example, Huntingtin interacting protein 1). The structure ...

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Publication status:
Published

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Journal:
Science (New York, N.Y.)
Volume:
291
Issue:
5506
Pages:
1051-1055
Publication date:
2001-02-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:3d1ffdab-bf4a-4a18-9409-8b191e4d83d9
Source identifiers:
196865
Local pid:
pubs:196865

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