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Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection

Abstract:

HIV-1 transmission is associated with a severe bottleneck in which a limited number of variants from a pool of genetically diverse quasispecies establishes infection. The IAVI protocol C cohort of discordant couples, female sex workers, other heterosexuals and men who have sex with men (MSM) present varying risks of HIV infection, diverse HIV-1 subtypes and represent a unique opportunity to characterize transmitted/founder viruses (TF) where disease outcome is known. To identify the TF, the H...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1008853

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Role:
Author
ORCID:
0000-0002-5605-5604
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Role:
Author
ORCID:
0000-0002-8443-5559
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
16
Issue:
9
Article number:
e1008853
Publication date:
2020-09-04
Acceptance date:
2020-08-03
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pmid:
32886726

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