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Novel RNA-based strategies for therapeutic gene silencing.

Abstract:

The past decade has seen intense scientific interest in non-coding RNAs. In particular, the discovery and subsequent exploitation of gene silencing via RNA interference (RNAi) has revolutionized the way in which gene expression is now studied and understood. It is now well established that post-transcriptional gene silencing (PTGS) by the microRNA (miRNA) and other RNAi-associated pathways represents an essential layer of complexity to gene regulation. Gene silencing using RNAi additionally d...

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Publisher copy:
10.1038/mt.2009.306

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
18
Issue:
3
Pages:
466-476
Publication date:
2010-03-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:3d1548cc-4e27-4550-8bab-50b36cc61831
Source identifiers:
114281
Local pid:
pubs:114281

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