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TCR-mediated adhesion of T cell hybridomas to planar bilayers containing purified MHC class II/peptide complexes and receptor shedding during detachment.

Abstract:

T cell recognition of foreign Ag/MHC class II complexes is sensitive down to approximately 100 complexes per cell or approximately 0.2 complexes/micron2. To better understand the physical basis of the recognition stage of Ag presentation, we examined adhesion of the lysozyme- specific T cell hybridoma, 3A9, to artificial bilayers containing covalent MHC class II/peptide complexes or adhesion molecules. Adhesion of 3A9 cells required a superphysiologic density of the MHC class II/peptide compl...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Miller, JM More by this author
Ranganath, S More by this author
Vignali, DA More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
157
Issue:
5
Pages:
2014-2021
Publication date:
1996-09-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:3d0b4e8c-0fce-495c-873b-aa1ce77d14ae
Source identifiers:
482680
Local pid:
pubs:482680

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