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Determination of a molecular map position for Hyp using a new interspecific backcross produced by in vitro fertilization.

Abstract:

We have established a Mus spretus/Mus musculus domesticus interspecific backcross segregating for two X-linked mutant genes, Ta and Hyp, using in vitro fertilization. The haplotype of the recombinant X chromosome of each of 241 backcross progeny has been established using the X-linked anchor loci Otc, Hprt, Dmd, Pgk-1, and Amg and the additional probes DXSmh43 and Cbx-rs1. The Hyp locus (putative homologue of the human disease gene hypophosphatemic rickets, HYP) has been incorporated into the...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Genomics
Volume:
11
Issue:
3
Pages:
651-657
Publication date:
1991-11-05
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
URN:
uuid:3d0b11c0-ca50-468c-8668-28ed4e575456
Source identifiers:
25415
Local pid:
pubs:25415

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