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Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp.

Abstract:

We postulated that changes in cardiac high-energy phosphate metabolism may underlie the myocardial dysfunction caused by hypobaric hypoxia. Healthy volunteers (n=14) were studied immediately before, and within 4 d of return from, a 17-d trek to Mt. Everest Base Camp (5300 m). (31)P magnetic resonance (MR) spectroscopy was used to measure cardiac phosphocreatine (PCr)/ATP, and MR imaging and echocardiography were used to assess cardiac volumes, mass, and function. Immediately after returning f...

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Publication status:
Published

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Publisher copy:
10.1096/fj.10-172999

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
25
Issue:
2
Pages:
792-796
Publication date:
2011-02-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Language:
English
Keywords:
Pubs id:
pubs:105374
UUID:
uuid:3d0838bb-48d3-4e74-b09b-cfd88acf5ada
Local pid:
pubs:105374
Source identifiers:
105374
Deposit date:
2012-12-19

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