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Determinants of primaquine and carboxyprimaquine exposures in children and adults with Plasmodium vivax malaria

Abstract:
Background Primaquine is the only widely available drug for radical cure of Plasmodium vivax malaria. There is uncertainty whether the pharmacokinetic properties of primaquine are altered significantly in childhood or not.
Methods Glucose-6-phosphate dehydrogenase normal patients with uncomplicated P. vivax malaria were randomized to receive either chloroquine (25mg base/kg) or dihydroartemisinin-piperaquine (dihydroartemisinin 7mg/kg and piperaquine 55m... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/aac.01302-21

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-5524-0325
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
65
Issue:
11
Article number:
e01302-21
Publication date:
2021-08-16
Acceptance date:
2021-08-11
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
34398667
Language:
English
Keywords:
Pubs id:
1191318
Local pid:
pubs:1191318
Deposit date:
2021-08-30

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