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Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development.

Abstract:

Cranial dermis develops from cephalic mesoderm and neural crest cells, but what signal(s) specifies the dermal lineage is unclear. Using genetic tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital region, we show that the dermal progenitor cells beneath the surface ectoderm process canonical Wnt signaling at the time of specification. We show that Wnt signaling/β-catenin is absolutely required and sufficient for Dermo1 expression and dermal cell id...

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Publisher copy:
10.1242/dev.056473

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Journal:
Development (Cambridge, England)
Volume:
137
Issue:
23
Pages:
3973-3984
Publication date:
2010-12-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:3cf02d32-79e6-49f8-88d3-77a13a2e4cd9
Source identifiers:
324507
Local pid:
pubs:324507

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