Sequence effects of single base loops in intramolecular quadruplex DNA.

Journal article

We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1',2'-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2 degrees C). Quadruplexes containing loops with single A residues were less stable by 8 degrees C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel ...

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Authors: Rachwal, P; Brown, T; Fox, K

• Publication status: Published
• Journal: FEBS letters
• Volume: 581
• Issue: 8
• Pages: 1657-1660
• Publication date: 2007-04-01
• DOI: 10.1016/j.febslet.2007.03.040
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: Oligonucleotides; Deoxyribose; Nucleic Acid Conformation; DNA; Base Sequence; Thermodynamics; G-Quadruplexes