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The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene.

Abstract:

Wilson disease (WD) is an autosomal recessive disorder of copper transport, resulting in copper accumulation and toxicity to the liver and brain. The gene (WD) has been mapped to chromosome 13 q14.3. On yeast artificial chromosomes from this region we have identified a sequence, similar to that coding for the proposed copper binding regions of the putative ATPase gene (MNK) defective in Menkes disease. We show that this sequence forms part of a P-type ATPase gene (referred to here as Wc1) tha...

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Publication status:
Published

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Publisher copy:
10.1038/ng1293-327

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Nature genetics
Volume:
5
Issue:
4
Pages:
327-337
Publication date:
1993-12-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
167195

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