- Abstract:
-
A strong HLA association is seen in coeliac disease [specifically to the DQ(alpha1*0501,beta1*0201 heterodimer], but this cannot entirely account for the increased risk seen in relatives of affected cases. One or more genes at HLA-unlinked loci also predispose to coeliac disease and are probably stronger determinants of disease susceptibility than HLA. A recent study has proposed a number of candidate regions on chromosomes 6p23 (distinct from HLA), 6p12, 3q27, 5q33.3, 7q31.3, 11p11, 15q26, 1...
Expand abstract - Publisher copy:
- 10.1093/hmg/6.8.1335
-
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- Journal:
- Human molecular genetics
- Volume:
- 6
- Issue:
- 8
- Pages:
- 1335-1339
- Publication date:
- 1997-08-05
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
- URN:
-
uuid:3ce3c663-3dc8-4908-9427-8c21c670032e
- Source identifiers:
-
72325
- Local pid:
- pubs:72325
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Linkage analysis of candidate regions for coeliac disease genes.
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