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Linkage analysis of candidate regions for coeliac disease genes.

Abstract:

A strong HLA association is seen in coeliac disease [specifically to the DQ(alpha1*0501,beta1*0201 heterodimer], but this cannot entirely account for the increased risk seen in relatives of affected cases. One or more genes at HLA-unlinked loci also predispose to coeliac disease and are probably stronger determinants of disease susceptibility than HLA. A recent study has proposed a number of candidate regions on chromosomes 6p23 (distinct from HLA), 6p12, 3q27, 5q33.3, 7q31.3, 11p11, 15q26, 1...

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Publisher copy:
10.1093/hmg/6.8.1335

Authors


Houlston, RS More by this author
Tomlinson, IP More by this author
Marossy, AM More by this author
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Journal:
Human molecular genetics
Volume:
6
Issue:
8
Pages:
1335-1339
Publication date:
1997-08-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:3ce3c663-3dc8-4908-9427-8c21c670032e
Source identifiers:
72325
Local pid:
pubs:72325

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