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The effect of anti-TNF-alpha therapy on spinal bone mineral density in patients with Crohn's disease.

Abstract:

Proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) might be, at least partially, responsible for the development of osteopenia or osteoporosis in Crohn's disease. We investigated whether anti-TNF therapy for Crohn's disease could have any skeletal impact. Therefore, we studied the effects of infliximab, a monoclonal antibody against TNF-alpha with and without bisphosphonates, on spinal bone mineral density (BMD). The effect of corticosteroids was also analyzed. A ret...

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Publisher copy:
10.1196/annals.1346.055

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Annals of the New York Academy of Sciences
Volume:
1068
Issue:
1
Pages:
543-556
Publication date:
2006-04-05
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:3cdf9c41-f1c1-4fe1-8e97-c6d18e74dee7
Source identifiers:
263227
Local pid:
pubs:263227

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