Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line.

Journal article

Small cell lung carcinoma (SCLC) is a tumour of neuroendocrine origin often found in association with autoimmune paraneoplastic neurological disorders. We established a SCLC cell line from a woman with Lambert-Eaton myasthenic syndrome (LEMS) who developed antibodies to both the P/Q-type voltage-gated calcium channels (VGCC) and the muscle acetycholine receptor (AChR). We used a range of techniques to establish which neuronal antigens were expressed in her tumour cell line. The results show t...

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Authors: Benatar, M; Blaes, F; Johnston, I; Wilson, K; Vincent, A

• Publication status: Published
• Journal: Journal of neuroimmunology
• Volume: 113
• Issue: 1
• Pages: 153-162
• Publication date: 2001-02-01
• DOI: 10.1016/s0165-5728(00)00431-8
• EISSN: 1872-8421
• ISSN: 0165-5728
• Language: English
• Keywords: Gene Expression; Synaptotagmins; Serotonin; Receptors, Cholinergic; Autoantibodies; Tumor Cells, Cultured; Presynaptic Terminals; Calcium; Calcium Channels, P-Type; Motor Neurons; Nerve Tissue Proteins; Tritium; Calcium-Binding Proteins; Carcinoma, Small Cell; Calcium Channels; Calcium Channels, Q-Type; Humans; Membrane Glycoproteins