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Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in the Netherlands.

Abstract:

The prevalence of mutations at amino acid (aa) position 315 in the katG gene of isoniazid (INH)-resistant Mycobacterium tuberculosis isolates in The Netherlands and the mutation's association with the level of INH resistance, multidrug resistance, and transmission were determined. Of 4288 M. tuberculosis isolates with available laboratory results, 295 (7%) exhibited INH resistance. Of 148 aa 315 mutants, 89% had MICs of 5-10 microg/mL, whereas 75% of the other 130 INH-resistant strains had MI...

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Publication status:
Published

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Publisher copy:
10.1086/317598

Authors


van Soolingen, D More by this author
de Haas, PE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Kuijper, E More by this author
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Journal:
The Journal of infectious diseases
Volume:
182
Issue:
6
Pages:
1788-1790
Publication date:
2000-12-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:3cd4f41b-8a85-470f-b686-ffc4509c818c
Source identifiers:
113020
Local pid:
pubs:113020

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