Journal article
Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in the Netherlands.
- Abstract:
-
The prevalence of mutations at amino acid (aa) position 315 in the katG gene of isoniazid (INH)-resistant Mycobacterium tuberculosis isolates in The Netherlands and the mutation's association with the level of INH resistance, multidrug resistance, and transmission were determined. Of 4288 M. tuberculosis isolates with available laboratory results, 295 (7%) exhibited INH resistance. Of 148 aa 315 mutants, 89% had MICs of 5-10 microg/mL, whereas 75% of the other 130 INH-resistant strains had MI...
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- Publication status:
- Published
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- Publisher copy:
- 10.1086/317598
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Bibliographic Details
- Journal:
- Journal of infectious diseases
- Volume:
- 182
- Issue:
- 6
- Pages:
- 1788-1790
- Publication date:
- 2000-12-01
- DOI:
- EISSN:
-
1537-6613
- ISSN:
-
0022-1899
- Source identifiers:
-
113020
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:113020
- UUID:
-
uuid:3cd4f41b-8a85-470f-b686-ffc4509c818c
- Local pid:
- pubs:113020
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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