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A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.

Abstract:

Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non-insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15-20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identification of new MODY genes. This will potentially enable further dissection of clinical heterogeneity ...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.52.3.872

Authors


Frayling, TM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Chevre, JC More by this author
Wishart, M More by this author
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Journal:
Diabetes
Volume:
52
Issue:
3
Pages:
872-881
Publication date:
2003-03-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:3cc8d74d-fcb0-4f99-be10-3d48eecdfd39
Source identifiers:
29057
Local pid:
pubs:29057

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