Journal article
Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations
- Abstract:
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Mutations in the isocitrate dehydrogenase genes (IDH1/2) occur often in diffuse gliomas, where they are associated with abnormal accumulation of the oncometabolite 2-hydroxyglutarate (2-HG). Monitoring 2-HG levels could provide prognostic information in this disease, but detection strategies that are noninvasive and sufficiently quantitative have yet to be developed. In this study, we address this need by presenting a proton magnetic resonance spectroscopy (1H-MRS) acquisition scheme that use...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Accepted manuscript, pdf, 242.6KB)
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- Publisher copy:
- 10.1158/0008-5472.CAN-15-0934
Authors
Funding
National Institute for Health Research
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Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Research Journal website
- Volume:
- 76
- Issue:
- 1
- Pages:
- 43-49
- Publication date:
- 2015-12-15
- DOI:
- EISSN:
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1538-7445
- ISSN:
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0008-5472
Item Description
- Keywords:
- Pubs id:
-
pubs:581385
- UUID:
-
uuid:3cc63877-74bd-4723-bc36-bed3237ff0f3
- Local pid:
- pubs:581385
- Source identifiers:
-
581385
- Deposit date:
- 2016-01-07
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2015
- Notes:
- © 2015 American Association for Cancer Research. This is the accepted manuscript version of the article. The final version is available online from American Association for Cancer Research at: [10.1158/0008-5472.CAN-15-0934]
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