Intraventricular pentosan polysulphate in human prion diseases: an observational study in the UK.

Journal article

UNLABELLED: BACKGROUND, PURPOSE AND METHODS: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK. RESULTS: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11-110 microg/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deteriorat...

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Authors: Bone, I; Belton, L; Walker, A; Darbyshire, J

• Publication status: Published
• Journal: European journal of neurology : the official journal of the European Federation of Neurological Societies
• Volume: 15
• Issue: 5
• Pages: 458-464
• Publication date: 2008-05-01
• DOI: 10.1111/j.1468-1331.2008.02108.x
• EISSN: 1468-1331
• ISSN: 1351-5101
• Language: English
• Keywords: Treatment Outcome; Female; Humans; Observation; Injections, Intraventricular; Follow-Up Studies; Prion Diseases; Neurologic Examination; Great Britain; Middle Aged; Adult; Pentosan Sulfuric Polyester; Magnetic Resonance Imaging; Anticoagulants; Male