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Meiotic recombination, cross-reactivity, and persistence in Plasmodium falciparum.

Abstract:

We incorporate a representation of Plasmodium falciparum recombination within a discrete-event model of malaria transmission. We simulate the introduction of a new parasite genotype into a human population in which another genotype has reached equilibrium prevalence and compare the emergence and persistence of the novel recombinant forms under differing cross-reactivity relationships between the genotypes. Cross-reactivity between the parental (initial and introduced) genotypes reduces the fr...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Evolution; international journal of organic evolution
Volume:
55
Issue:
7
Pages:
1299-1307
Publication date:
2001-07-01
DOI:
EISSN:
1558-5646
ISSN:
0014-3820
Source identifiers:
37900
Language:
English
Keywords:
Pubs id:
pubs:37900
UUID:
uuid:3cc3a65a-5389-4c33-8a2a-cb5ddb5bdd39
Local pid:
pubs:37900
Deposit date:
2012-12-19

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