Tin protoporphyrin provides protection following cerebral hypoxia-ischemia: involvement of alternative pathways.

Journal article

The contribution of heme oxygenase (HO)-linked pathways to neurodegeneration following cerebral hypoxia-ischemia (HI) remains unclear. We investigated whether HO modulators affected HI-induced brain damage and explored potential mechanisms involved. HI was induced in 26-day-old male Wistar rats by left common carotid artery ligation, followed by exposure to a humidified atmosphere of 8% oxygen for 1 hr. Tin protoporphyrin (SnPP; an HO inhibitor), ferriprotoporphyrin (FePP; an HO inducer), or ...

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Authors: Sutherland, B; Shaw, O; Clarkson, A; Winburn, I; Errington, A

• Publication status: Published
• Journal: Journal of neuroscience research
• Volume: 89
• Issue: 8
• Pages: 1284-1294
• Publication date: 2011-08-01
• DOI: 10.1002/jnr.22661
• EISSN: 1097-4547
• ISSN: 0360-4012
• Language: English
• Keywords: Animals; Hemin; Heme Oxygenase (Decyclizing); Brain; Protoporphyrins; Male; Hypoxia-Ischemia, Brain; Rats; Prostaglandin-Endoperoxide Synthases; Rats, Wistar; Enzyme Inhibitors; Electron Transport Complex IV; Nitric Oxide Synthase; Metalloporphyrins; Electron Transport Complex I