Journal article
A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152.
- Abstract:
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Two mutant virus strains in which the novel P225H mutation appeared in a V106A reverse transcriptase (RT)-mutated genetic background upon treatment of human immunodeficiency virus type 1 (HIV-1) with quinoxaline S-2720 were isolated. Surprisingly, the addition of the P225H mutation to the V106A RT mutant genetic background resensitized the V106A RT mutant virus to the non-nucleoside RT inhibitor (NNRTI) BHAP U-90152, but not to other NNRTIs. Construction of both recombinant viruses and recomb...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of general virology More from this journal
- Volume:
- 79 ( Pt 6)
- Issue:
- 6
- Pages:
- 1347-1352
- Publication date:
- 1998-06-01
- EISSN:
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1465-2099
- ISSN:
-
0022-1317
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:14074
- UUID:
-
uuid:3cbc5dad-b53f-4659-9075-4d207a67b552
- Local pid:
-
pubs:14074
- Source identifiers:
-
14074
- Deposit date:
-
2012-12-19
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- Copyright date:
- 1998
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