Journal article
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors.
- Abstract:
- The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some β-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical communications Journal website
- Volume:
- 57
- Pages:
- 1430-1433
- Publication date:
- 2021-01-19
- Acceptance date:
- 2020-11-23
- DOI:
- EISSN:
-
1364-548X
- ISSN:
-
1359-7345
- Pmid:
-
33462575
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1157600
- Local pid:
- pubs:1157600
- Deposit date:
- 2021-02-19
Terms of use
- Copyright holder:
- The Royal Society of Chemistry
- Copyright date:
- 2021
- Rights statement:
- Copyright The Royal Society of Chemistry 2021. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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