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Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage.

Abstract:

A spectrum of in vivo-expressed Staphylococcus aureus antigens was identified by probing bacteriophage expression libraries of S. aureus with serum samples from infected and uninfected individuals. Eleven recombinant antigenic proteins were produced, and specific antibody titers in a large collection of human serum samples were determined. Significantly increased concentrations of reactive immunoglobulin G (IgG) to 7 antigens were found in serum samples from ill individuals, compared with tho...

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Publication status:
Published

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Publisher copy:
10.1086/501471

Authors


Clarke, SR More by this author
Brummell, KJ More by this author
Horsburgh, MJ More by this author
McDowell, PW More by this author
Mohamad, SA More by this author
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Journal:
The Journal of infectious diseases
Volume:
193
Issue:
8
Pages:
1098-1108
Publication date:
2006-04-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:3cad5077-1724-4e68-a57c-6f1e6879b37d
Source identifiers:
20175
Local pid:
pubs:20175

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