Expression profiling of repetitive elements by melting temperature analysis: variation in HERV-W gag expression across human individuals and tissues.
BACKGROUND: Human endogenous retroviruses (HERV) constitute approximately 8% of the human genome and have long been considered "junk". The sheer number and repetitive nature of these elements make studies of their expression methodologically challenging. Hence, little is known of transcription of genomic regions harboring such elements. RESULTS: Applying a recently developed technique for obtaining high resolution melting temperature data, we examined the frequency distributions of HERV-W ga...Expand abstract
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- Copyright 2009 Nellåker et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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