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Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.

Abstract:

alpha-Cells were identified in preparations of dispersed mouse islets by immunofluorescence microscopy. A high fraction of alpha-cells correlated with a small cell size measured as the average cell diameter (10 microm) and whole-cell capacitance (<4 pF). The alpha-cells generated action potentials at a low frequency (1 Hz) in the absence of glucose. These action potentials were reversibly inhibited by elevation of the glucose concentration to 20 mmol/l. The action potentials originated fro...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.49.9.1500

Authors


Galvanovskis, J More by this author
Göpel, SO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Eliasson, L More by this author
Journal:
Diabetes
Volume:
49
Issue:
9
Pages:
1500-1510
Publication date:
2000-09-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:3ca35771-2ccb-4597-89f5-0898cc3972de
Source identifiers:
23395
Local pid:
pubs:23395

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