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Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.

Abstract:

Remote ischemic preconditioning reduces myocardial infarction (MI) in animal models. We tested the hypothesis that the systemic protection thus induced is effective when ischemic preconditioning is administered during ischemia (PerC) and before reperfusion and examined the role of the K(+)-dependent ATP (K(ATP)) channel. Twenty 20-kg pigs were randomized (10 in each group) to 40 min of left anterior descending coronary artery occlusion with 120 min of reperfusion. PerC consisted of four 5-min...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00617.2006

Authors


Schmidt, MR More by this author
Konstantinov, IE More by this author
Shimizu, M More by this author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
292
Issue:
4
Pages:
H1883-H1890
Publication date:
2007-04-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:3c9be6fd-9170-4ab8-919f-d27a5254ca0d
Source identifiers:
105151
Local pid:
pubs:105151

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