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Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes.

Abstract:

AIMS: Spontaneous Ca2+ waves in cardiomyocytes are potentially arrhythmogenic. A powerful controller of Ca2+ waves is the cytoplasmic H+ concentration ([H+]i), which fluctuates spatially and temporally in conditions such as myocardial ischaemia/reperfusion. H+-control of Ca2+ waves is poorly understood. We have therefore investigated how [H+]i co-ordinates their initiation and frequency.

METHODS AND RESULTS: Spontaneous Ca2+ waves were imaged (fluo-3) in rat isolated v...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/cvr/cvx033

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Corpus Christi College
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Grant:
RG/08/016 and RG15/9/31534/
Wellcome Trust More from this funder
Royal Society More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
113
Issue:
8
Pages:
984-995
Publication date:
2017-02-21
Acceptance date:
2016-02-17
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Pubs id:
pubs:687273
URN:
uri:3c983538-7ad8-4948-b6fc-322b6284a7d5
UUID:
uuid:3c983538-7ad8-4948-b6fc-322b6284a7d5
Local pid:
pubs:687273

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