- Abstract:
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AIMS: Spontaneous Ca2+ waves in cardiomyocytes are potentially arrhythmogenic. A powerful controller of Ca2+ waves is the cytoplasmic H+ concentration ([H+]i), which fluctuates spatially and temporally in conditions such as myocardial ischaemia/reperfusion. H+-control of Ca2+ waves is poorly understood. We have therefore investigated how [H+]i co-ordinates their initiation and frequency.
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METHODS AND RESULTS: Spontaneous Ca2+ waves were imaged (fluo-3) in rat isolated v... - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.5mb)
-
- Publisher copy:
- 10.1093/cvr/cvx033
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cardiovascular Research Journal website
- Volume:
- 113
- Issue:
- 8
- Pages:
- 984-995
- Publication date:
- 2017-02-21
- Acceptance date:
- 2016-02-17
- DOI:
- EISSN:
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1755-3245
- ISSN:
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0008-6363
- Pubs id:
-
pubs:687273
- URN:
-
uri:3c983538-7ad8-4948-b6fc-322b6284a7d5
- UUID:
-
uuid:3c983538-7ad8-4948-b6fc-322b6284a7d5
- Local pid:
- pubs:687273
- Copyright holder:
- Ford et al.
- Copyright date:
- 2017
- Notes:
- © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
Journal article
Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes.
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