Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes.
AIMS: Spontaneous Ca2+ waves in cardiomyocytes are potentially arrhythmogenic. A powerful controller of Ca2+ waves is the cytoplasmic H+ concentration ([H+]i), which fluctuates spatially and temporally in conditions such as myocardial ischaemia/reperfusion. H+-control of Ca2+ waves is poorly understood. We have therefore investigated how [H+]i co-ordinates their initiation and frequency.Expand abstract
METHODS AND RESULTS: Spontaneous Ca2+ waves were imaged (fluo-3) in rat isolated v...
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Oxford University Press Publisher's website
- Cardiovascular Research Journal website
- Publication date:
- Acceptance date:
- Pubs id:
- Local pid:
- Paper number:
- Copyright holder:
- Ford et al.
- Copyright date:
- © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record