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Ophiobolin A, a sesterpenoid fungal phytotoxin, displays different mechanisms of cell death in mammalian cells depending upon the cancer cell origin

Abstract:

Herein we have undertaken a systematic analysis of the effects of the fungal derivative ophiobolin A (OphA) on eight cancer cell lines from different tissue types. The LD50 for each cell line was determined and the change in cell size determined. Flow cytometric analysis and western blotting were used to assess the cell death markers for early apoptosis, late apoptosis and necrosis, and the involvement of the caspase signalling pathway. Alterations in calcium levels and reactive oxygen specie...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3892/ijo.2017.3858

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Women's and Reproductive Health
Role:
Author
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Funding agency for:
Morrison, R
Grant:
EP/G036861/1
More from this funder
Funding agency for:
Townley, H
Publisher:
Spandidos Publications Publisher's website
Journal:
International Journal of Oncology Journal website
Volume:
50
Issue:
3
Pages:
773-786
Publication date:
2017-01-19
Acceptance date:
2016-12-15
DOI:
ISSN:
1791-2423 and 1019-6439
Source identifiers:
675087
Language:
English
Keywords:
Pubs id:
pubs:675087
UUID:
uuid:3c9655eb-f216-46a1-ab16-a6ffce800c9b
Local pid:
pubs:675087
Deposit date:
2017-02-15

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