Journal article
Ophiobolin A, a sesterpenoid fungal phytotoxin, displays different mechanisms of cell death in mammalian cells depending upon the cancer cell origin
- Abstract:
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Herein we have undertaken a systematic analysis of the effects of the fungal derivative ophiobolin A (OphA) on eight cancer cell lines from different tissue types. The LD50 for each cell line was determined and the change in cell size determined. Flow cytometric analysis and western blotting were used to assess the cell death markers for early apoptosis, late apoptosis and necrosis, and the involvement of the caspase signalling pathway. Alterations in calcium levels and reactive oxygen specie...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 856.3KB)
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- Publisher copy:
- 10.3892/ijo.2017.3858
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Authors
Funding
+ RCUK Digital Economy Programme
More from this funder
Funding agency for:
Morrison, R
Grant:
EP/G036861/1
Bibliographic Details
- Publisher:
- Spandidos Publications Publisher's website
- Journal:
- International Journal of Oncology Journal website
- Volume:
- 50
- Issue:
- 3
- Pages:
- 773-786
- Publication date:
- 2017-01-19
- Acceptance date:
- 2016-12-15
- DOI:
- ISSN:
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1791-2423 and 1019-6439
- Source identifiers:
-
675087
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:675087
- UUID:
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uuid:3c9655eb-f216-46a1-ab16-a6ffce800c9b
- Local pid:
- pubs:675087
- Deposit date:
- 2017-02-15
Terms of use
- Copyright holder:
- © Morrison et al
- Copyright date:
- 2017
- Notes:
- This is an open access article distributed under the terms of Creative Commons Attribution License
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