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Journal article

T cell sensitivity to HLA class I-mediated apoptosis is dependent on interleukin-2 and interleukin-4.

Abstract:

Antibody interaction with a specific epitope of the HLA class I alpha1 domain triggers apoptosis of activated but not resting T and B cells by a pathway which involves neither Fas ligand nor tumor necrosis factor-alpha. We have investigated at which stage of activation and proliferation T cells become sensitive to HLA class I-mediated apoptosis, using two monoclonal antibodies (mAb) which recognize the same monomorphic epitope of the HLA class I alpha1 domain (mAb9O, mouse IgG1, and YTH862, r...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830270221

Authors


Genestier, L More by this author
Paillot, R More by this author
Bonnefoy-Berard, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Revillard, JP More by this author
Journal:
European journal of immunology
Volume:
27
Issue:
2
Pages:
495-499
Publication date:
1997-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:3c933f52-f4ff-411b-8539-59b60084e4b7
Source identifiers:
12472
Local pid:
pubs:12472

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