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Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment

Abstract:

Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of SLI which included parent-of-origin effects and child genotype effects and used 278 families of language-impaired children. The child genotype effects analysis did not identify significant associations. We found genome-wide significant paternal parent-of-origin effects on chromosome 14q12 (P=3.74...

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Publisher copy:
10.1111/gbb.12127

Authors


Simpson, NH More by this author
Conti-Ramsden, G More by this author
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Publisher:
Blackwell Publishing Ltd
Journal:
Genes, Brain and Behavior
Volume:
13
Issue:
4
Pages:
418-429
Publication date:
2014
DOI:
EISSN:
1601-183X
ISSN:
1601-1848
URN:
uuid:3c7de768-93bf-40f7-bff0-13bb7d05adf1
Source identifiers:
463617
Local pid:
pubs:463617

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