- Abstract:
-
It is thought that the anti-inflammatory effects of glucocorticoids (GCs) are largely due to GC receptor (GR)-mediated transrepression of NF-κB and other transcription factors, whereas side effects are caused by activation of gene expression (transactivation). Selective GR modulators (SGRMs) that preferentially promote transrepression should retain anti-inflammatory properties whilst causing fewer side effects. Contradicting this model, we found that anti-inflammatory effects of the classical...
Expand abstract - Publisher copy:
- 10.1111/j.1476-5381.2011.01574.x
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- Journal:
- Br J Pharmacol
- Volume:
- 165
- Issue:
- 4b
- Pages:
- 1124-1136
- Publication date:
- 2012-02-05
- DOI:
- EISSN:
-
1476-5381
- URN:
-
uuid:3c77027a-e965-4fd9-a862-642220088fd8
- Source identifiers:
-
226448
- Local pid:
- pubs:226448
- Language:
- English
- Keywords:
- Copyright date:
- 2012
- Notes:
- PMCID: PMC3346253
Journal article
Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1.
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