Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.

Journal article

The role of genes in normal birth-weight variation is poorly understood, and it has been suggested that the genetic component of fetal growth is small. Type 2 diabetes genes may influence birth weight through maternal genotype, by increasing maternal glycemia in pregnancy, or through fetal genotype, by altering fetal insulin secretion. We aimed to assess the role of the recently described type 2 diabetes gene TCF7L2 in birth weight. We genotyped the polymorphism rs7903146 in 15,709 individual...

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Authors: Freathy, R; Weedon, M; Bennett, A; Hypponen, E; Relton, C

• Publication status: Published
• Journal: American journal of human genetics
• Volume: 80
• Issue: 6
• Pages: 1150-1161
• Publication date: 2007-06-01
• DOI: 10.1086/518517
• EISSN: 1537-6605
• ISSN: 0002-9297
• Language: English
• Keywords: Genetic Variation; Genotype; Alleles; Diabetes Mellitus, Type 2; Risk Factors; Male; Polymorphism, Genetic; Humans; Female; Transcription Factor 7-Like 2 Protein; Pregnancy; Gestational Age; TCF Transcription Factors; Glucokinase; Birth Weight