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A correlation between in vivo and in vitro effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on myxamoebae of Physarum polycephalum.

Abstract:

The effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on the growth of myxamoebae of Physarum polycephalum were closely paralleled by the effects of these drugs on the assembly in vitro of purified amoebal microtubule protein. Colchicine at 100 microM did not inhibit amoebal growth and did not inhibit formation, or depolymerization, of amoebal microtubules. The benzimidazole carbamate derivatives nocodazole and parbendazole were very effective in both inhibiting gr...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of general microbiology
Volume:
122
Issue:
1
Pages:
1-6
Publication date:
1981-01-01
ISSN:
0022-1287
Source identifiers:
2814
Language:
English
Keywords:
Pubs id:
pubs:2814
UUID:
uuid:3c7167cf-1578-4c8c-8ea7-1eb905cdca5d
Local pid:
pubs:2814
Deposit date:
2012-12-19

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