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A correlation between in vivo and in vitro effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on myxamoebae of Physarum polycephalum.

Abstract:

The effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on the growth of myxamoebae of Physarum polycephalum were closely paralleled by the effects of these drugs on the assembly in vitro of purified amoebal microtubule protein. Colchicine at 100 microM did not inhibit amoebal growth and did not inhibit formation, or depolymerization, of amoebal microtubules. The benzimidazole carbamate derivatives nocodazole and parbendazole were very effective in both inhibiting gr...

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Publication status:
Published

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Authors


Quinlan, RA More by this author
Pogson, CI More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Journal of general microbiology
Volume:
122
Issue:
1
Pages:
1-6
Publication date:
1981-01-05
ISSN:
0022-1287
URN:
uuid:3c7167cf-1578-4c8c-8ea7-1eb905cdca5d
Source identifiers:
2814
Local pid:
pubs:2814

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