Maternal HLA homozygosity and mother-child HLA concordance increase the risk of vertical transmission of HIV-1.

Journal article

BACKGROUND: Mother-child human leukocyte antigen (HLA) concordance and maternal HLA homozygosity may increase the risk of vertical transmission of human immunodeficiency virus type 1 (HIV-1) risk by reducing infant immune responses. METHODS: We analyzed mother-child HLA concordance and maternal HLA homozygosity in a Kenyan perinatal cohort receiving antenatal zidovudine. HLA concordance was scored as the number of shared class I alleles, and relative risk estimates were adjusted for maternal ...

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Authors: Mackelprang, R; John-Stewart, G; Carrington, M; Richardson, B; Rowland-Jones, S

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 197
• Issue: 8
• Pages: 1156-1161
• Publication date: 2008-04-01
• DOI: 10.1086/529528
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: DNA, Viral; HIV-1; Polymerase Chain Reaction; Homozygote; Infectious Disease Transmission, Vertical; HLA Antigens; Cohort Studies; Female; Breast Feeding; Pregnancy Complications, Infectious; Proportional Hazards Models; Pregnancy; Milk, Human; Infant, Newborn; Humans; RNA, Viral; HIV Infections