Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells.

Journal article

BACKGROUND: The outcome of virus infection depends from the precise coordination of viral gene expression and genome replication. The ability to control and regulate these processes is therefore important for analysis of infection process. Viruses are also useful tools in bio- and gene technology; they can efficiently kill cancer cells and trigger immune responses to tumors. However, the methods for constructing tissue- or cell-type specific viruses typically suffer from low target-cell spec...

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Authors: Viru, L; Heller, G; Lehto, T; Pärn, K; Andaloussi, S

• Journal: Virology journal
• Volume: 8
• Issue: 1
• Pages: 243
• Publication date: 2011-01-01
• DOI: 10.1186/1743-422x-8-243
• EISSN: 1743-422X
• ISSN: 1743-422X
• Language: English
• Keywords: Virus Replication; Alternative Splicing; Genetic Engineering; Biotechnology; Genetic Vectors; Introns; Gene Expression; Hela Cells; Molecular Biology; Gene Expression Regulation, Viral; Humans; Virology