Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.

Journal article

1. The beta-cell K(ATP) channel is composed of two types of subunit - the inward rectifier K(+) channel (Kir6.2) which forms the channel pore, and the sulphonylurea receptor (SUR1), which serves as a regulatory subunit. The N-terminus of Kir6.2 is involved in transduction of sulphonylurea binding into channel closure, and deletion of the N-terminus (Kir6.2DeltaN14) results in functional uncoupling of the two subunits. In this study, we investigate the interaction of the hypoglycaemic agents r...

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Authors: Hansen, A; Hansen, J; Carr, R; Ashcroft, F; Wahl, P

• Publication status: Published
• Journal: British journal of pharmacology
• Volume: 144
• Issue: 4
• Pages: 551-557
• Publication date: 2005-02-01
• DOI: 10.1038/sj.bjp.0706082
• EISSN: 1476-5381
• ISSN: 0007-1188
• Language: English
• Keywords: Drug Interactions; Hypoglycemic Agents; Cell Membrane; Patch-Clamp Techniques; Islets of Langerhans; Piperidines; Receptors, Drug; ATP-Binding Cassette Transporters; Humans; Potassium Channels, Inwardly Rectifying; Binding, Competitive; Mice; Carbamates; Animals; Cell Line; Potassium Channels