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Journal article

Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1+ KLRG1− CD4+ T cells

Abstract:

BCG, the only vaccine licensed against tuberculosis, demonstrates variable efficacy in humans. Recent preclinical studies highlight the potential for mucosal BCG vaccination to improve protection. Lung tissue-resident memory T cells reside within the parenchyma, potentially playing an important role in protective immunity to tuberculosis. We hypothesised that mucosal BCG vaccination may enhance generation of lung tissue-resident T cells, affording improved protection against Mycobacterium tub...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41385-018-0109-1

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM: Jenner Institute
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM: Experimental Medicine
Pasricha, J More by this author
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Funding agency for:
McShane, H
Publisher:
Springer Nature Publishing Group Publisher's website
Journal:
Mucosal Immunology Journal website
Volume:
12
Pages:
555–564
Publication date:
2018-11-16
Acceptance date:
2018-10-27
DOI:
ISSN:
1933-0219 and 1935-3456
Pubs id:
pubs:944798
URN:
uri:3c52a566-d8e7-4612-8393-950f03b99b18
UUID:
uuid:3c52a566-d8e7-4612-8393-950f03b99b18
Local pid:
pubs:944798
Language:
English

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