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Journal article

Compromised redox homeostasis, altered nitroso-redox balance and therapeutic possibilities in atrial fibrillation

Abstract:

Although the initiation, development and maintenance of atrial fibrillation (AF) has been linked to alterations in myocyte redox state, the field lacks a complete understanding of the impact these changes may have on cellular signalling, atrial electrophysiology, and disease progression. Recent studies demonstrate spatiotemporal changes in reactive oxygen species production shortly after the induction of AF in animal models with an uncoupling of nitric oxide synthase activity ensuing in the p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1093/cvr/cvw012

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
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Grant:
RG/11/15/29375; CH/12/3/29609
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Grant:
n°261057 (EUTRAF)
Medical Research Council More from this funder
Publisher:
Oxford University Press (OUP): Policy B - Oxford Open Option B - CC-BY Publisher's website
Journal:
Cardiovascular Research Journal website
Publication date:
2016-01-26
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
URN:
uuid:3c4f1227-e3f4-4d82-9000-c3a766ff60e6
Source identifiers:
591866
Local pid:
pubs:591866

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