- Abstract:
-
Programmed -1 ribosomal frameshifting is employed in the expression of a number of viral and cellular genes. In this process, the ribosome slips backwards by a single nucleotide and continues translation of an overlapping reading frame, generating a fusion protein. Frameshifting signals comprise a heptanucleotide slippery sequence, where the ribosome changes frame, and a stimulatory RNA structure, a stem-loop or RNA pseudoknot. Antisense oligonucleotides annealed appropriately 3' of a slipper...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/nar/gks629
-
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- Journal:
- Nucleic acids research
- Volume:
- 40
- Issue:
- 17
- Pages:
- 8674-8689
- Publication date:
- 2012-09-05
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
- URN:
-
uuid:3c4a4ca5-834a-4fb6-a289-a40281c51e84
- Source identifiers:
-
341073
- Local pid:
- pubs:341073
- Copyright date:
- 2012
Journal article
Spacer-length dependence of programmed -1 or -2 ribosomal frameshifting on a U6A heptamer supports a role for messenger RNA (mRNA) tension in frameshifting.
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