Journal article icon

Journal article

Spacer-length dependence of programmed -1 or -2 ribosomal frameshifting on a U6A heptamer supports a role for messenger RNA (mRNA) tension in frameshifting.

Abstract:

Programmed -1 ribosomal frameshifting is employed in the expression of a number of viral and cellular genes. In this process, the ribosome slips backwards by a single nucleotide and continues translation of an overlapping reading frame, generating a fusion protein. Frameshifting signals comprise a heptanucleotide slippery sequence, where the ribosome changes frame, and a stimulatory RNA structure, a stem-loop or RNA pseudoknot. Antisense oligonucleotides annealed appropriately 3' of a slipper...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/nar/gks629

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Brierley, I More by this author
Journal:
Nucleic acids research
Volume:
40
Issue:
17
Pages:
8674-8689
Publication date:
2012-09-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:3c4a4ca5-834a-4fb6-a289-a40281c51e84
Source identifiers:
341073
Local pid:
pubs:341073

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP