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Journal article

Spacer-length dependence of programmed -1 or -2 ribosomal frameshifting on a U6A heptamer supports a role for messenger RNA (mRNA) tension in frameshifting.

Abstract:

Programmed -1 ribosomal frameshifting is employed in the expression of a number of viral and cellular genes. In this process, the ribosome slips backwards by a single nucleotide and continues translation of an overlapping reading frame, generating a fusion protein. Frameshifting signals comprise a heptanucleotide slippery sequence, where the ribosome changes frame, and a stimulatory RNA structure, a stem-loop or RNA pseudoknot. Antisense oligonucleotides annealed appropriately 3' of a slipper...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gks629

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Nucleic acids research
Volume:
40
Issue:
17
Pages:
8674-8689
Publication date:
2012-09-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:341073
UUID:
uuid:3c4a4ca5-834a-4fb6-a289-a40281c51e84
Local pid:
pubs:341073
Source identifiers:
341073
Deposit date:
2012-12-19

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