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A logic-based dynamic modeling approach to explicate the evolution of the central dogma of molecular biology

Abstract:

It is nearly half a century past the age of the introduction of the Central Dogma (CD) of molecular biology. This biological axiom has been developed and currently appears to be all the more complex. In this study, we modified CD by adding further species to the CD information flow and mathematically expressed CD within a dynamic framework by using Boolean network based on its present-day and 1965 editions. We show that the enhancement of the Dogma not only now entails a higher level of compl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0189922

Authors


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ORCID:
0000-0002-6991-8587
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
CR BDI-NDM
Azimzadeh, S More by this author
Mirzaie, M More by this author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
12
Pages:
Article: e0189922
Publication date:
2017-12-21
Acceptance date:
2017-12-05
DOI:
ISSN:
1932-6203
Pubs id:
pubs:827864
URN:
uri:3c429da7-c287-4cfd-8157-d9ab78504f42
UUID:
uuid:3c429da7-c287-4cfd-8157-d9ab78504f42
Local pid:
pubs:827864
Language:
English

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