Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.

Journal article

Tau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase. GSK-3beta is part of the wingless signalling pathway and stimulation by wingless is predicted to down-regulate GSK-3beta activity. In Drosophila imaginal disc cells, overexpression of dishevelled, a component of the wingless pathway, mimics the wingless signal. We have therefore studied the effect that overexpression of the murine dishevelled-1 protein has on GSK-3beta-m...

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Authors: Wagner, U; Brownlees, J; Irving, N; Lucas, F; Salinas, P

• Publication status: Published
• Journal: FEBS letters
• Volume: 411
• Issue: 2-3
• Pages: 369-372
• Publication date: 1997-07-01
• DOI: 10.1016/s0014-5793(97)00733-3
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: Glycogen Synthase Kinase 3; Drosophila; Cloning, Molecular; tau Proteins; Adaptor Proteins, Signal Transducing; Signal Transduction; Humans; Calcium-Calmodulin-Dependent Protein Kinases; Phosphorylation; Mice; Insect Proteins; Cricetinae; Transfection; Animals; CHO Cells; Blotting, Western; Gene Expression Regulation; Phosphoproteins