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A comparison of chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline with doxycycline alone as maintenance therapy for melioidosis.

Abstract:

A prospective, open, randomized, comparative treatment trial was conducted to compare the therapeutic efficacy of the conventional four-drug combination (chloramphenicol, trimethoprim-sulfamethoxazole, and doxycycline) with that of doxycycline alone in oral maintenance treatment of melioidosis. Adult Thai patients with culture-confirmed melioidosis were randomized to receive treatment with either regimen for a minimum of 12 weeks, usually following intravenous treatment of severe disease. The...

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Publication status:
Published

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Publisher copy:
10.1086/520218

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
29
Issue:
2
Pages:
375-380
Publication date:
1999-08-01
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
Source identifiers:
37160

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