Journal article
AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells
- Abstract:
-
Purpose. To determine whether human X-linked inhibitor of apoptosis (XIAP) enhances the survival of cultured human retinal pigment epithelial cells exposed to H 2O 2. Methods. ARPE-19 cells were exposed to H 2O 2 to induce oxidative cell death. Intracellular reactive oxygen species (ROS) were measured using 2′,7′-dichlorofluorescein diacetate. MTT assay was performed to quantify mitochondrial stress. Cell apoptosis was determined by TUNEL assay. Human XIAP was delivered with bicistronic expre...
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- Publisher copy:
- 10.1167/iovs.10-6850
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Authors
Bibliographic Details
- Journal:
- Investigative Ophthalmology and Visual Science
- Volume:
- 52
- Issue:
- 13
- Pages:
- 9591-9597
- Publication date:
- 2011-12-01
- DOI:
- EISSN:
-
1552-5783
- ISSN:
-
0146-0404
- Source identifiers:
-
344593
Item Description
- Language:
- English
- Pubs id:
-
pubs:344593
- UUID:
-
uuid:3c33f4af-e969-4952-a502-d465fc90a3e3
- Local pid:
- pubs:344593
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2011
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