Journal article
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
- Abstract:
-
Cyclic dinucleotides (CDNs) are important second messenger molecules in prokaryotes and eukaryotes. Within host cells, cytosolic CDNs are detected by STING and alert the host by activating innate immunity characterized by type I interferon (IFN) responses. Extracellular bacteria and dying cells can release CDNs, but sensing of extracellular CDNs (eCDNs) by mammalian cells remains elusive. Here, we report that endocytosis facilitates internalization of eCDNs. The DNA sensor cGAS facilitates se...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Reports Journal website
- Volume:
- 20
- Issue:
- 4
- Article number:
- e46293
- Publication date:
- 2019-03-14
- Acceptance date:
- 2019-02-12
- DOI:
- EISSN:
-
1469-3178
- ISSN:
-
1469-221X
- Pmid:
-
30872316
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:984887
- UUID:
-
uuid:3c336618-9f72-4160-8916-2ed3a98a305e
- Local pid:
- pubs:984887
- Source identifiers:
-
984887
- Deposit date:
- 2019-04-12
Terms of use
- Copyright date:
- 2019
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from EMBO Press at: 10.15252/embr.201846293
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