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Thesis

Characterizing the function of the Arl15 gene and its role in the development of metabolic traits

Abstract:

The ARL15 human Genome Wide Association (GWA) locus is associated with increased risk of type 2 diabetes, lower plasma adiponectin, higher fasting plasma insulin, sexually dimorphic altered body composition, lower HDL cholesterol and lipodystrophy. Knocking down ARL15 in a human β cell line is reported to result in impaired insulin secretion. ARL15 belongs to the small GTPase ARF family and is predicted to be involved in vesicle trafficking. The aim of this thesis was to test the Arl...

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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