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Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

Abstract:

BALB/c mice infected with the intracellular protozoan Leishmania major mount a T helper cell 2 (Th2) response that fails to control growth of the parasite and results in the development of visceral leishmaniasis. Separation of CD4+ T cells into CD45RBhigh and CD45RBlow subsets showed that the L. major-specific Th2 cells were contained within the CD45RBlow population as these cells produced high levels of antigen-specific interleukin 4 (IL-4) in vitro and transferred a nonhealing response to L...

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Publication status:
Published

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Publisher copy:
10.1084/jem.179.2.589

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Correa-Oliveira, R More by this author
Coffman, RL More by this author
Journal:
The Journal of experimental medicine
Volume:
179
Issue:
2
Pages:
589-600
Publication date:
1994-02-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:3c25bca1-b13d-4d82-9f59-2a12034a8b98
Source identifiers:
16068
Local pid:
pubs:16068

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